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FIRST INTERNATIONAL INSTITUTE FOR COMPLEX ADAPTIVE MATTER (I2CAM) EXPLORATORY WORKSHOP on PROTEIN AGGREGATION AND AMYLOID FORMATION IN SYSTEMIC AND NEURODEGENERATIVE DISEASE: PHYSICAL, MOLECULAR AND BIOLOGICAL APPROACHES 16-19 July 2005,
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Scientific Program
Day 1 - Saturday 16 th July8:30 – 9:00 Introduction by the organisers
Opening Lecture 1.
Protein misfolding and aggregation in the cell. Why, where, when and how it occurs?
09:00 – 09:45 Chris Dobson ( University of Cambridge, UK)
Question 1.
What have we learned from studying amyloid fibril formation in vitro and what is the relevance of these findings to the biology of amyloid diseases?
09:45 – 10:10 Jeffery Kelly (Scripps Research Institute, California, USA)
10:10 – 10:25 Sheena Radford ( University of Leeds, UK)
10:25 – 10:45 Coffee break
10:45 – 11:10 Fabrizio Chiti ( University of Florence, Italy)
11:10 – 11:35 Luis Serrano (EMBL Heidelberg, Germany)
11:35 – 12:00 Eckhard Mandelkow (Hamburg Max Planck Institute, Germany)
12:00 – 12:40 General Discussion
12:45 – 14:30 Lunch
Question 2
What are the best approaches for probing the secondary and quaternary structural changes occurring during the early events of protein oligomerization and amyloid formation in vitro and in vivo?
02:40 – 03:05 Ralf Langen ( University of California San Francisco, USA)
03:05 – 03:30 Omar El-Agnaf (United Arab Emirate University, UAE)
03:30 – 03:55 Holger Wille ( University of California San Francisco, USA)
03:55 – 04:15 Coffee/Tea break
04:15 – 04:40 Manfred Mutter(Swiss Federal Inst. of Tech.-Lausanne, Switzerland)
04:40 – 05:05 Giovannie Dietler (Swiss Federal Inst. of Tech.-Lausanne, Switzerland)
05:05 – 05:50 General discussion
Day 2 - Sunday 17 th July
Opening Lecture 2.
What are the current state of knowledge and prevailing hypotheses concerning the role of protein aggregation and amyloid formation in Neurodegenerative and systemic amyloid Diseases?
09:00 – 09:45 Christopher Ross (John’s Hopkins University, USA)
Question 3.
What are the mechanisms by which protein aggregates cause neurodegeneration and cell dysfunction and degeneration?
09:45 – 10:10 Erich Wanker ( Max Delbruck Center for Mol. Med., Berlin, Germany)
10:10 – 10:25 Coffee Break
10:25 – 10:50 Poul Henning Jensen ( University of Aarhus, Denmark)
10:50 – 11:15 Nelson Arispe (National Institute of Health, USA)
11:15 – 11:40 Charles Glabe ( University of California Irvine, USA)
11:40 – 12:25 General Discussion
12:15 – 14:15 Lunch
Question 4.
Can prions or other amyloid proteins play a role in the molecular basis for synaptic plasticity and nervous system development?
02:00 – 02:25 Ralph Zahn (ETH, Zurich, Switzerland)
02:25 – 02:50 Kenneth Moya (CEA Orsay, France)
02:50 – 03:15 Sylvan Lehmann (CNRS Montpellier, France)
03:15 – 03:40 General Disucssion
03:40 – 06:00 Poster Session
Day 3 - Monday 18 th July
Question 5.
Which intermediate species (monomers, dimers, oligomers, or protofibrils) formed along the amyloid formation pathway is the pathogenic species? If there are more than one pathogenic species, what are the implications for developing amyloid based therapeutic strategies for these diseases? What are the best approaches for separating the culprits from innocent bystanders?
09:00 – 09:25 Dominic Walsh ( University College, Dublin, Ireland)
09:25 – 09:50 David Harris ( Washington University St. Louis, USA)
09:50 – 10:15 Joel Buxbaum (The Scripps Research Institute, California, USA)
10:15 – 10:45 Coffee break
10:45 – 11:10 Byron Caughey (NIH/NIAID, Rocky Mountians Laboratories, USA)
11:10 – 12:05 General Discussion
12.15 – 02:30 Lunch
Question 6.
What have we learned from cellular and animal models of amyloid diseases and how have these models been used or can be used to elucidate the missing links between protein aggregation and disease and test the current hypotheses about the etiology of these diseases?
02:30 – 02:55 Adriano Aguzzi ( University of Zurich, Switzerland)
02:55 – 03:20 Patrick Aebischer (Swiss Federal Inst. of Tech.-Lausanne, Switzerland)
03:20 – 03:50 Masliah Eliezer ( University of California San Diego, USA)
03:50 – 04:10 Coffee Break
04:10 – 04:35 Seung-Jae Lee (Parkinson’s Institute, California, USA)
04:35 – 05:00 Nasser Zawia ( University of Rhode Island, USA)
05:00 – 05:40 General Discussion
07:00 – 10:00 Dinner on the lake (boat cruise)
Day 4 - Tuesday 19 th JulyQuestion 7.
What can theoretical and computational modeling of peptide and protein self- assembly contribute to elucidating the molecular mechanisms of amyloid formation?
09:00 – 09:25 Daniel Cox ( University of California Davis, USA)
09:25 – 09:50 Rohit Pappu ( Washington University St Louis, USA)
10:15 – 10:40 Michele Vendruscolo ( University of Cambridge, UK)
10:40 – 11:00 Coffee break
11:00 – 11:25 Sichun Yang ( University of California San Diego, USA)
Question 8
Can amyloid structures and kinetics inspire new developments in materials science, either as direct elements or as analogues?
11:25 – 11:50 Joel Schneider ( University of Delaware, USA)
11:50 – 12:15 Cait MacPhee ( University of Cambridge, UK)
12:15 – 12:50 General Discussion
12:50 – 1:00 Concluding Remarks
01:00 – 02:30 Lunch